6 reasons to try grape seed extract

This powerful compound can improve heart health, weight management, mood and more

Grape seed extract, made from ground grape seeds, contains high levels of proanthocyanidins, the polyphenols that give grapes their deep red and purple colors. Heralded by its powerful activity as an antioxidant, Grape The popularity of seed extract as a functional food has risen.

In 2020, the grape seed extract market exceeded $135 million, and the compound annual growth rate is expected to reach 7.5 percent by 2027.[i]

While this is partly due to its use in cosmetics, personal care products, and other new products — such as nanofibers containing grape seed extract powder, which are incorporated into food packaging to prevent oxidation in food — health-conscious consumers are increasingly interested in Grape seed extract as a supplement or addition to functional foods and beverages.[ii] If you are considering giving it a try, here are some of its most important benefits.

1. Obesity prevention and management

Multiple actions, including lowering blood lipids, improving intestinal flora, and regulating metabolism, make grape seed extract useful for obesity. It can effectively prevent obesity In many ways,” wrote researchers from Yangtze University School of Medicine in Jingzhou, China.[iii]

When taken along with a calorie-restricted diet, grape seed extract (300 milligrams (mg) daily for 12 weeks) improved cardiovascular disease risk factors among adults who were obese or overweight.[iv] Compared to a placebo, the levels of beneficial high-density lipoprotein cholesterol increased in those who took grape seed extract while their low-density lipoprotein cholesterol decreased significantly.

Visceral fat, plasma atherosclerosis index (a marker of cardiovascular disease), and triglycerides were also significantly decreased in the grape seed extract group.

2. Support blood pressure

Grape seed extract It appears to have blood pressure lowering effects, in addition to heart rate lowering properties.[v] In healthy adults, taking grape seed extract (300 mg daily for 16 weeks) significantly modified blood pressure compared to a placebo.[vi] While among obese and overweight men, grape seed extract reduced arterial pressure at rest and during exercise, by significantly reducing aortic stiffness.[vii]

Even among people with metabolic syndrome, the potent vasodilating phenolic compounds in grape seed extract were effective, lowering systolic and diastolic blood pressure compared to placebo.[viii] Grape seed extract has also been suggested as an intervention to reduce the potential increase in cardiovascular events that can occur during exercise in people with high blood pressure.

While the placebo treatment had no effect, grape seed extract — taken as a single dose before exercise — lowered blood pressure, peripheral vasoconstriction, and cardiac functioning, while enhancing oxygen delivery among the hypertensive men.[ix]

3. Relieve stress and improve mood

Perceived stress and other mental components can have a significant impact on blood pressure. This is why researchers not only measured the effects of grape seed extract on blood pressure but also on participants’ cognition levels. Stress. Grape seed extract resulted in a surprising mood benefit associated with stress perception, including a statistically significant reduction in anxiety.[x]

Previous research similarly found that menopausal women who took grape seed extract had lower systolic blood pressure along with improvements in psychological symptoms such as anxiety.[xi] The mood benefits can be attributed to the polyphenols present in grape seed extract, which are associated with improved mood and increased cognitive function along with protective effects against brain diseases.[xii]

4. Dental health support

A systematic review of 20 studies revealed that grape seed extract has unique properties that facilitate the prevention of tooth decay. In addition to inhibiting bacterial biofilms on tooth surfaces, grape seed extract helped promote tooth remineralization, a natural process that helps repair tooth enamel before a cavity appears.[xiii]

Grape seed extract’s many properties—including being antibacterial, antioxidant, and anti-inflammatory—make it ideal for promoting oral health and managing gum disease.[xiv] Grape seed extract gel also resulted in significant improvements in gingival and plaque indices in people with chronic periodontitis.[xv]

5. Improve insulin resistance

Grape seed extract, with its powerful anti-inflammatory and antioxidant effects, may have many beneficial effects for diabetes, including improving insulin resistance. Among adolescents with metabolic syndrome, taking grape seed extract for eight weeks (100 mg per day) improved insulin concentration and insulin resistance.[xvi]

The polyphenols in grape seed extract also affect neuroregulatory factors and nerve signaling pathways, which may have a beneficial effect on insulin. Regarding diabeticGrape seed extract has a positive effect on starch-digesting enzymes in humans, and also improves the condition of patients with microalbuminuria,[xvii] An early sign of blood vessel damage[xviii] This is present in about 37 percent of people with type 2 diabetes and often precedes the development of diabetic nephropathy.[xix]

6. Heart health

In addition to lowering blood pressure, grape seed extract offers a number of additional benefits for heart health. Research indicates that it significantly reduces C-reactive protein (CRP) levels.[xx] CRP can reveal your risk of developing heart and blood vessel problems. Grape seed extract also helps prevent atherosclerosis, or hardening of the arteries, by:[xxi]

  • Reduce the oxidation of low-density lipoprotein
  • lowering blood pressure
  • reduce inflammation
  • Prevent platelet aggregation
  • Activation of some proteins, which prevents the aging of cells

Grape seed extract also helps reduce lipid accumulation in adipose tissue and even prevent the absorption of dietary fats through its effect on lipid metabolic enzymes.[xxii] Overall, the natural grape compound exerts powerful effects that reduce oxidative stress in the heart, helping to reduce heart weakness.[xxiii]

GreenMedInfo.com has compiled an impressive 86 drug actions associated with grape seed extract, as well as 190 diseases that may affect it.[xxiv] When taken in moderate amounts, grape seed extract is usually well-tolerated, according to the National Institutes of Health’s National Center for Complementary and Integrative Health.

Studies in humans of up to 11 months support its safety.[xxv] But for optimal use and dosage, consult your holistic healthcare practitioner.


[i] Global Market Insights, Grape Seed Extract Market Size, Base Year 2020 https://www.gminsights.com/industry-analysis/grape-seed-extracts-market

[ii] Global Market Insights, Grape Seed Extract Market Size, Base Year 2020 https://www.gminsights.com/industry-analysis/grape-seed-extracts-market

[iii] Obesity facts. 2020 May; 13 (2): 279–291. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250358/

[iv] Phytother Res. 2021 Feb; 35 (2): 987-995. doi: 10.1002/ptr.6859. Epub 2020 Oct 12. https://pubmed.ncbi.nlm.nih.gov/33044768/

[v] Pharmacol Res. 2022 Jan; 175: 105905. doi: 10.1016/j.phrs.2021.105905. Epub 2021 Nov 17, https://pubmed.ncbi.nlm.nih.gov/34798267/

[vi] Nutrients. 2021 Feb; 13 (2): 654. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7922661/

[vii] Eur J Sport Sci. 2021 May 20: 1-8. Epub 2021 May 20, PMID: 33905304 www.greenmedinfo.com/article/grape-seed-extract-can-be-dietary-supplement-treat-augmented-blood-pressure-re

[viii] Metabolism. 2009 Dec; 58 (12): 1743-6. doi: 10.1016/j.metabol.2009.05.030. Epub 2009 Jul 15. https://pubmed.ncbi.nlm.nih.gov/19608210/

[ix] J Med Food. 2018 May; 21 (5): 445-453. doi: 10.1089/jmf.2017.0133. Epub 2018 April 23. https://pubmed.ncbi.nlm.nih.gov/29683391/

[x] Nutrients. 2021 Feb 17; 13 (2). Epub 2021 Feb 17, PMID: 33671310 www.greenmedinfo.com/article/grape-seed-extract-positively-modules-blood-pressure-and-perceived-stress

[xi] Nutrients. 2021 Feb 17; 13 (2). Epub 2021 Feb 17.

[xii] Nutrients. 2021 Feb 17; 13 (2). Epub 2021 Feb 17, PMID: 33671310 www.greenmedinfo.com/article/grape-seed-extract-positively-modules-blood-pressure-and-perceived-stress

[xiii] Neuter Health. 2020 March; 26 (1): 43-52. doi: 10.1177/0260106019887890. Epub 2019 Nov 24. https://pubmed.ncbi.nlm.nih.gov/31760860/

[xiv] J Biol Regul Homeost Agents. March-April 2021; 35 (2 Supplement 1): 89-96. doi: 10.23812/21-2supp1-8. https://pubmed.ncbi.nlm.nih.gov/34281305/

[xv] J Investig Clin Dent. 2018 May; 9(2): e12318. doi: 10.1111/jicd.12318. Epub 2018 Jan 18. https://pubmed.ncbi.nlm.nih.gov/29349878/

[xvi] Diabetic metabolic syndrome. January to February 2021; 15 (1): 197-203. doi: 10.1016/j.dsx.2020.12.028. Epub 2020 Dec 23. www.greenmedinfo.com/article/grape-seed-extract-improves-insulin-concentration-and-insulin-resistance-adole

[xvii] Molecules. 2020 November; 25 (22): 5311. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7696942/

[xviii] Hippocratia. 2007 Jul-Sep 11(3):105-107. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658722/

[xix] Indian J Nephrul. 2009 April; 19 (2): 53-56. doi: 10.4103/0971-4065.5322 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2847808/

[xx] Br J Nutr. 2020 Sep 14:1-41. Epub 2020 Sep 14, PMID: 32921322 www.greenmedinfo.com/article/effect-grape-products-containing-polyphenols-c-reactive-protein-levels

[xxi] J Food Sci Technol. 2020 April; 57 (4): 1205–1215. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054588/

[xxii] J Food Sci Technol. 2020 April; 57 (4): 1205–1215. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054588/

[xxiii] J Food Sci Technol. 2020 April; 57 (4): 1205–1215. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054588/

[xxiv] GreenMedInfo.com, Grape Seed Extract www.greenmedinfo.com/substance/grape-seed-extract

[xxv] NIH National Center for Complementary and Integrative Health, Grape Seed Extract https://www.ncih.nih.gov/health/grape-seed-extract

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