More scientists are exploring cellular aging – a condition in which cells no longer divide.
Senescent cells, which accumulate in older bodies, are associated with age-related conditions such as dementia and cardiovascular disease.
Scientists are exploring drugs that target senescent cells. But experts say the most promising tool against the negative effects of senescent cells is exercise.
‘Very hot topic’
Viviana Perez Montes of the National Institutes of Health describes cellular aging as “extremely hot Title. The Associated Press reports that about 11,500 projects involving cellular aging have been initiated since 1985. The Associated Press report was based on its study of the National Institutes of Health research database. The report stated that a large number of projects began in recent years.
Such research is based on the idea that cells stop dividing and go into a state of “senescence” in response to damage. The body expels most of these cells.
But others remain in the body. It can harm nearby cells, says Nathan Librasor of the Mayo Clinic. He likened it to the way a bad fruit can spoil a bowl full of fruit.
But scientists wonder: Can the unhealthy accumulation of senescent cells be stopped?
“The ability to understand aging… is truly the greatest Chance We have had, perhaps in history, to Transformation Librasur says. Prolonging years of health, he said, affects “quality of life” and “public health”.
The number of people aged 65 or over worldwide is expected to double by 2050.
Although no one believes that old age is the key to a very long life, Tufts University researcher Christopher Wylie hopes there will be one less day when he suffers like his grandfather before death. He was suffering from Alzheimer’s disease.
“I’m not looking for the fountain of youth“I look for the fountain of non-illness when I grow up,” Wiley says.
About 100 companies, as well as academic groups, are exploring drugs to target senescent cells.
Scientists are keen to note that cell aging can be beneficial. The process may have evolved at least in part to suppress the development of cancer. Cell aging occurs throughout our lives, due to things like DNA damage and shortening of telomeres, the structures that protect the ends of chromosomes. Senescent cells play a role in wound healing, fetal development, and childbirth.
But problems can arise when senescent cells accumulate.
“When you’re young, your immune system is able to recognize and eliminate these aging cells,” says Perez, who studies cell biology and aging. But as we begin to get older, Perez puts it, “Our immune system becomes more active as well shrinkso we lose eligibility to eliminate them.”
Experimental drugs designed to remove senescent cells have been called “senogenic.” In mice, it has been shown to be effective in delaying, preventing, or relieving many age-related disorders.
at least 12 Patients Trials of antigeriatric drugs are now testing whether the drugs can help control Alzheimer’s disease, improve skeletal health, and more.
There is still much to learn.
Today, LeBrasseur, who runs a center on aging in Mayo, says exercise is “the most promising tool we have” for good health in late life, and its power extends into our cells.
Research shows that exercise prevents the buildup of aging cells, helping the immune system get rid of them and fight molecular damage that can affect the aging process.
Last year, LeBrasseur led a study that provided the first evidence in humans that exercise significantly affected exercise. Reduces signs in the bloodstream of the effect of aging cells in the body.
After a 12-week exercise program, researchers found that older adults had reduced signs of aging and improved muscle strength, physical ability, and reported health. A recently published research review gathers more evidence – in animals and humans – for exercise as a treatment that targets aging.
While such studies are not well known outside scientific circles, many older adults associate exercise with younger adults.
Rancher put Mike Gill, 81, on the track and field throwing circuit on his big California property. He and some of his friends threw the discus and used other exercise equipment.
“I’d like to compete in my ’90s,” says Gill. “why not?”
Richard Soler, 95, says exercise keeps him fit enough to handle whatever comes his way — including the discovery that his 62-year-old wife had Alzheimer’s disease. The two sometimes walk the streets of their neighborhood together, holding each other’s hands.
“Do whatever you can,” he says. “This should be anyone’s goal to stay healthy.”
I’m John Russell.
And I’m Ashley Thompson.
Laura Ungar wrote about this story for the Associated Press. John Russell adapted it for VOA Learning English.
The words in this story
Title – n. A person or thing that people talk about or write about
Chance – n. The amount of time or situation in which something can be done
Transformation – Fifth. To change (something) completely and usually in a good way
the fountain of youth – expression A legendary fountain that is supposed to give eternal youth to those who drink from it
decrease – Fifth. To become or make (something) less significant, etc.
eligibility – n. The ability to do something: a mental, emotional, or physical ability
Patients – Related to or based on work done with real patients: or related to medical treatment given to patients in hospitals, clinics, etc.